Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo

Retinol-Binding Protein 4 in Twins

OBJECTIVE Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose metabolism. RESEARCH DESIGN AND METHODS ...

Retinol-binding protein 4 in human obesity.

Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes. In contrast to the animal data, RBP4 mRNA was downregulated in subcutaneous...

The Effect of 8 Weeks Interval Exercises and Vitamin D Supplementation on Plasma Levels of Dipeptidyl peptidase-4 and Retinol Binding Protein 4 in Overweight Women

Abstract Over weight is one of the most important public health concerns and the most common fat metabolism disorder in humans the purpose of this study was to compare the effect of eight weeks of interval training and vitamin D intake on DPP4 and RBP4 plasma levels of overweight with mean age of 39.92±4.15 , height 159.25±3.8 cm weight 72.73 kg /m2 in this study , 40 subjects were selected pur...

Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease

OBJECTIVE Retinol-binding protein 4 (RBP4) is a recently identified adipokine that is elevated in the serum in several insulin-resistant states. We investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and serum RBP4 in nondiabetic adults. METHODS One hundred and fifty-nine nondiabetic, non-alcoholic subjects (95 males and 64 females) participated in this study. Divi...

hev-capsid protein interacts with cytochrome p4502c8 and retinol-binding protein 4